Caring for your brain health might be the smartest wellness goal you can make—and nutrition can help. Foods like green tea, leafy greens, and fish are well-known for their brain-boosting benefits. Several nutrients and herbs may also enhance brain performance. (1)
Whether your goal is to maintain a sharp mind as you age or to boost your daily brainpower, starting with nutritious food is essential. Yet, we all know that maintaining a perfect diet isn’t always easy. That’s where dietary supplements can step in to bridge the nutritional gaps.
Our team of dietitians and health professionals has meticulously reviewed a wide array of popular brain health supplements to help you decide if they’re right for you. Here are our top seven supplements for brain health.
Editors choice: Ritual Omega-3 DHA & EPA
Ritual Omega-3 DHA & EPA earns our pick for editor’s choice. It provides 500 mg of essential fatty acids for brain health that many people aren’t getting enough of in their diets. Plus it uses a novel source (microalgae) that’s better-tasting and more eco-friendly than typical omega-3 fish supplements. You can read our full review below.
Medical disclaimer: This article is intended for educational and informational purposes only. It is not intended as a substitute for medical advice. For health advice, contact a licensed healthcare provider.
Our picks for the best brain supplement
- Best for adults: Transparent Labs Dopamine
- Best natural: Ritual Omega-3 DHA & EPA
- Best for brain fog: Onnit Alpha Brain
- Best mushroom supplement: Legion Athletics Elevate
- Best for seniors: Olly Ultra Strength Brain Softgels
- Best for brain function: Lifeforce Magnesium
- Best for menopause brain fog: Ancient Nutrition Regenerative Organic Certified Focused Brain
Compare brain supplements
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| Ritual Omega-3 DHA & EPA | Transparent Labs Dopamine | Onnit Alpha Brain | Legion Athletics Elevate | Olly Ultra Strength Brain Softgels | Lifeforce Magnesium | Ancient Nutrition Regenerative Organic Certified Focused Brain | |
| Rating | |||||||
| Price per serving | $1.10 | $1.33 | $2.33 | $1.67 | $0.83 | $2.17 | $1.33 |
| Key ingredients | Omega-3 EPA plus DHA | Vitamin B6, Folate, L-tyrosine, CDP-choline, oroxylin A, saffron | Vitamin B6, Cat’s claw extract Onnit Flow Blend, Onnit Focus Blend, Onnit Fuel Blend | Organic reishi , Organic lion’s mane, yeast beta-glucan | Vitamin B6, vitamin B12, blueberry extract, bacopa extract, Omega-3 from fish oil | Magnesium l-threonate, magnesium bisglycinate chelate, magnesium N-acetyltaurinate, dimagnesium malate, magnolia extract | Vitamin B12, lion’s mane, bacopa, ginkgo, bacillus subtilis AB22 |
| Serving size | 1 capsule | 4 capsules | 2 capsules | 1 scoop | 2 softgels | 4 capsules | 3 capsules |
Best brain supplement for adults: Transparent Labs Dopamine+
Key product features
What you should know
Transparent Labs Dopamine+ is designed to help boost brainpower, especially under stress. It uses a blend of six active ingredients to support dopamine production, which plays a role in mood, attention, and learning.
- The recommended four-capsule dose of Transparent Labs Dopamine+ is quite high, making it less ideal for those who dislike taking pills.
- At $1.33 per serving, this supplement is on the expensive side, but a subscription option offers discounts and free shipping.
- This stimulant-free supplement may help people seeking a mental boost without the jittery effects of caffeine.
- The combination of ingredients in this product has limited clinical support.
Why we like Transparent Labs Dopamine+ as best for adults
Transparent Labs Dopamine+ is designed to support cognitive performance during times of high stress, making it ideal for busy adults.
The supplement contains six active ingredients: vitamin B6, folate, L-tyrosine, CDP-choline, oroxylin A, and saffron, which together aim to support dopamine production and function. Dopamine is a neurotransmitter that positively affects mood, attention, and learning, among other things. (10) Stress can deplete dopamine and impair cognitive function. (11, 12) This product strives to address this issue.
According to Transparent Labs, a four-capsule dose is recommended to support dopamine production, limit its breakdown, and enhance dopamine receptors, so that you can perform and feel your best even under the most demanding conditions. We understand that four capsules can be overwhelming, so this supplement isn’t a great option if you don’t like taking pills.
Aside from this, we appreciate that Transparent Labs provides full visibility into their ingredients, dosages, and supporting research. Some ingredients like tyrosine and CDP-choline show promise for enhancing cognitive performance, but others like saffron and oroxylin A have less clinical support. (13, 14)
It’s worth noting that while Transparent Labs aims to use clinically-tested dosages, there are no standard dosage recommendations for these ingredients to enhance dopamine levels or brain performance. Furthermore the lack of research on this specific combination of ingredients makes it hard to determine overall effectiveness and safety, which is a common drawback of multi-ingredient products.
Since Transparent Labs Dopamine+ is stimulant-free, it may be appealing to those seeking a mental boost without the jittery effects of caffeine. Keep in mind some of these ingredients may interact with other medications you’re taking, so it’s best to discuss whether or not this supplement is right for you with a healthcare professional.
At $1.33 per serving, this product is on the expensive side of things. It only comes in a 30-day supply, but a subscription option offers discounts and free shipping.
Specs
| Active ingredients | Vitamin B6 (0.44 milligrams), Folate (400 micrograms), L-tyrosine (1500 milligrams), Oroxylin A (500 milligrams), CDP-choline (250 milligrams), Saffron (30 milligrams) |
| Form | Capsule |
| Cost per serving | $1.33 |
| Additional ingredients | Hypromellose capsule, magnesium stearate, silicon dioxide |
| Certifications | Third-party tested |
| Special diets | Gluten-free, non-GMO |
| Returns/guarantee | 30-day return policy |
Best natural brain supplement: Ritual Omega-3 DHA & EPA
Key product features
What you should know
Ritual Omega-3 DHA & EPA supports long-term brain health by providing 500 milligrams of EPA and DHA in the ideal 2:1 ratio. By sourcing from microalgae instead of fish, Ritual overcomes common omega-3 supplement drawbacks like fishy aftertastes and sustainability issues.
- Ritual scored well in our review for ingredient transparency. Third-party testing and ingredient traceability on their website help assure customers they can trust the product.
- It’s pricey at $1.10 per capsule, but the quality, testing, and transparency of this supplement add to its value.
- The formula is vegan, gluten-free, and free from common allergens, making it ideal for those with dietary restrictions or those who don’t like fish.
- Eco-conscious consumers will appreciate the sustainable sourcing, net-zero carbon footprint goal, and recycled plastic packaging.
Why we like Ritual Omega-3 DHA & EPA as best natural
Ritual Omega-3 DHA & EPA features vegan-sourced omega-3 from whole microalgae, using natural flavors and a veggie-based capsule to avoid artificial additives. This simplicity sets it apart from other formulas that contain multiple ingredients and synthetic additives. Ritual’s formula also overcomes common drawbacks of omega-3 supplements, like taste and sustainability concerns.
There’s no question EPA and DHA are important to brain health. These fatty acids provide structure to brain cells and support neural communication. Additionally, their anti-inflammatory properties protect brain cells and the blood vessels that provide nutrients and oxygen to brain tissue. (2, 3)
Your body can’t make these fats, so you must get them from your diet. Fatty fish like salmon, tuna, and sardines are your best sources. Unfortunately, most people are falling short of the two weekly servings of fatty fish recommended by the American Heart Association. These two servings would provide the equivalent of about 500 milligrams of EPA plus DHA daily. (4) Considering how research links low levels of DHA in the blood with smaller brain sizes in adults, indicating poor brain health, this is definitely something most adults should be aware of. (5)
Supplements can effectively boost blood levels of both these important nutrients. (6) However, most EPA and DHA supplements are sourced from fish oil, making them a no-go for people following plant-based diets. Furthemore, omega-3 supplements have a reputation for leaving an unpleasant fishy aftertaste.
We love that Ritual addresses these concerns with their vegan omega-3 formula. Instead of fish, Ritual sources each capsule’s 500 milligrams of EPA and DHA from microalgae. Algae oil supplements are shown to be as effective as fish oil at boosting EPA and DHA levels. (7, 8) In fact, eating algae is how many fish get their high omega-3 fatty acid levels. (9)
This is great news for people following plant-based diets, but also a win for those who simply dislike the taste of seafood. Each Ritual capsule contains citrus oil to mask any off-tastes, eliminating a possible aftertaste.
Ritual’s ingredient integrity also impressed us. This product is third-party tested, and free of gluten and common allergens. So you don’t need to worry about mercury or other contaminants.
Eco-conscious consumers will appreciate that Ritual provides traceable details about their sourcing practices and is working towards a net-zero carbon footprint. They also use 100% recycled plastic for their packaging.
There is one key downside of Ritual: it’s expensive. Each serving costs $1.10, which is considerably higher than similar supplements on the market. It’s also worth noting each bottle only contains a month’s worth of product, so you’ll need to order frequently. However, they offer a thirty-day money back guarantee to help you assess the product’s value firsthand.
Check out our Ritual review for more in-depth information about this brand and its supplements.
What customers are saying
Amazon customers have given Ritual Omega-3 a 4.4 out of 5 average rating. Most customers are pleased with the taste and easy digestion of these capsules.
Reviewer Melissa praised the formulation for “great quantities of omega’s which I love.” As an added bonus she describes the capsules as “so easy to swallow and have a nice aftertaste!”
“This omega 3 has given me the same results as the brand I used in the past but perhaps the best thing it has is that the capsule is bathed in a light lemon-flavored oil that when you put it in your mouth is the flavor you feel, making it much more pleasant when taking it.”
Denise G., verified Amazon customer
Some customers note that the citrus flavor and aroma comes on strong. This isn’t a problem if you like citrus, but if you’d prefer to avoid it you may need a different product.
Reviewer Servo notes “I am still trying to figure out if I like the over the top citrus scent or not. Unfortunately the scent reminds me of a bathroom air freshener or something—a bit too strong.”
Specs
| Active ingredients | 500 milligrams omega-3 fatty acids (154 milligrams EPA plus 308 milligrams DHA) from algae oil |
| Form | Capsule |
| Cost per serving | $1.10 |
| Additional ingredients | Vegan capsule (hypromellose), silica, natural flavor (organic orange oil), mixed tocopherols |
| Certifications | Third-party tested, clean label project certified, certified carbon-free by the carbon fund |
| Special diets | Vegan, gluten-free, major allergen-free |
| Returns/guarantee | 30-day money back guarantee |
Best supplement for brain fog: Onnit Alpha Brain
Key product features
What you should know
Onnit’s Alpha Brain is a popular brain supplement designed to combat brain fog and enhance focus and memory by supporting neurotransmitter production and promoting alpha brain waves.
- Alpha Brain claims to boost cognitive function by supporting acetylcholine production and alpha brain waves. While customers generally report positive results, some say they’ve experienced side effects like nausea and headaches.
- This product is relatively expensive, costing $2.33 per dose, and lacks third-party testing to validate its safety and potency.
- Alpha Brain is best suited for individuals looking to enhance their cognitive abilities without stimulants, although it’s best to consult a doctor before use due to potential ingredient interactions.
- While some ingredients have clinical support, the proprietary blends make it difficult to verify the effective dosages used, and much of the research is still preliminary.
Why we like Onnit Alpha Brain as best for brain fog
Alpha Brain is designed specifically to enhance focus and memory by supporting acetylcholine production and promoting alpha brain waves. Acetylcholine is a neurotransmitter that plays a central role in memory and learning. (15) Brain waves represent braincell communication patterns and reflect our thoughts, moods, and states of consciousness. Alpha brain waves occur when your brain is in a relaxed state and are associated with creativity. (16)
Onnit’s Alpha Brain claims to enhance cognitive functions through its multi-ingredient formula, which includes vitamin B6, cat’s claw extract, and Onnit’s proprietary blends. The “Flow Blend” consists of L-tyrosine, L-theanine, oat extract, and phosphatidylserine. The “Focus Blend” features Alpha GPC, bacopa extract, toothed clubmoss, and Huperzine A. Finally, the “Fuel Blend” contains L-leucine and pterostilbene.
“Cat’s claw increases tryptophan, which has been shown to increase serotonin, increasing the brain’s relaxed state.”
Victoria Burgess, PhD, CSCS, CISSN, Fortune Recommends Advisor
Research supports a few of these ingredients. For example, L-theanine may help manage stress and increase focus and attention while bacopa extract may help support healthy acetylcholine levels. (17, 18, 19) However, much of this research is preliminary and is far from conclusive. And, since Onnit uses proprietary blends, it’s impossible to tell if the dosages match those used in clinical studies.
We would like to see this supplement go through third-party testing to validate safety and potency. Especially considering its heftier price tag ($2.33 per two-capsule dose), we think this extra measure would go a long way.
Despite these concerns, Onnit’s 90-day money-back guarantee may help you feel more willing to give it a go. But remember, due to potential interactions with this multi-ingredient supplement, it’s important to consult with a doctor before adding the product into your normal routine.
Check out our full Alpha brain review to read more and see additional products.
What customers are saying
Over 40,000 customers have rated Onnit Alpha Brain on Amazon. They give this product an average rating of 4.0 out of 5.
“Within the first couple of days, I noticed a difference. I followed the recommended dose of two capsules in the morning with a small meal. I have noticed an increase in focus and motivation. I feel more energized and motivated to complete my work and tasks. I would recommend to anyone to at least try it and see if you can feel a difference.”
James F., verified Amazon customer
While price is a common complaint, Amazon reviewer Bobby thinks the premium price is worth it, stating “Alpha Brain is a little pricey, but it does help get in the zone. Onnit makes good products and the premium for a nootropic is worth it.”
Notably, numerous customers report side effects like nausea and headaches when following the recommended two capsule dose. Some were able to resolve these issues by reducing the dosage to one capsule daily and taking with a meal.
Specs
| Active ingredients | Vitamin B6 (10 milligrams) Cat’s claw extract (350 milligrams) Onnit Flow Blend (650 milligrams): l-tyrosine, l-theanine, oat extract, and phosphatidylserine Onnit Focus Blend (240 milligrams): Alpha GPC, Bacopa extract, toothed clubmoss, Huperzine A Onnit Fuel Blend (60 milligrams): l-leucine and pterostilbene |
| Form | Capsule |
| Cost per serving | $2.33 |
| Additional ingredients | Maltodextrin, vegetarian capsule (hydroxypropyl methylcellulose), rice hull concentrate |
| Certifications | None |
| Special diets | Gluten-free, caffeine-free |
| Returns/guarantee | 90-day money-back guarantee |
Best mushroom supplement for brain health: Legion Athletics Elevate
Key product features
What you should know
Legion Elevate aims to support mental performance and long-term brain health with their combination of lion’s mane and reishi mushroom extracts.
- The Dutch chocolate flavored powder is a great alternative to capsules, easily mixing with coffee, smoothies, and more.
- At $1.67 per serving, this is an expensive option, but a subscription program offers savings, and there’s a no-return necessary money-back guarantee.
- This product is ideal for those seeking a natural, non-capsule supplement to help boost immediate brain performance and support lasting brain health.
Why we like Legion Elevate as best mushroom
Legion Elevate is our top pick for the best mushroom brain health supplement because it combines two mushroom extracts: lion’s mane and reishi. This pairing may offer both immediate and lasting brain health benefits.
Mushrooms have been used for centuries in traditional medicine. They’re rich in antioxidants, vitamin D, and other health-promoting bioactives. Recently, research has linked eating more mushrooms with reduced risks of cognitive decline. (20)
Lion’s mane, found in forests in North America, Asia, and Europe, may help improve mood and thinking skills in both young and older adults. One pilot study found that young participants completed cognitive tasks faster after a single 1.8-gram dose and experienced reduced stress after 28 days of use. (21)
Reishi mushrooms, found in East Asia, have potent anti-inflammatory effects. (22) These effects may support long-term brain health since inflammation is linked to worsening memory and cognitive function. (23) Legion Elevate also includes beta-glucan, a functional fiber, for its additional anti-inflammatory benefits.
We like that this product, which comes in a Dutch chocolate flavored powder, offers an alternative to capsules and pills. Natural sweetener (stevia) masks any mushroom flavors, so it works well mixed with coffee, smoothies, yogurt, and more. However, people on restricted diets should note that each scoop contains 30 calories and five grams of carbohydrates.
We also rated this product highly for ingredient quality and trust. It’s third-party tested for potency and contaminants, with results available on Legion’s website, ensuring you get what you pay for. Plus, Legion avoids artificial additives that might interfere with the product’s benefits.
A one-scoop serving costs $1.67, one of the more expensive options on our list. However, a subscription program is available to help you save on each order. For added peace of mind, Legion offers a no-return necessary money-back guarantee.
Specs
| Active ingredients | Organic reishi (2 grams), Organic lion’s mane (2 grams), Wellmune ® yeast beta-glucan (250 milligrams) |
| Form | Powder |
| Cost per serving | $1.67 |
| Additional ingredients | Natural flavors, cocoa powder, guar gum, salt, stevia |
| Certifications | Third-party tested |
| Special diets | Gluten-free, dairy-free, soy-free |
| Returns/guarantee | No return necessary money-back guarantee for first product up to 365 days |
Best brain supplement for seniors: Olly Ultra Strength Brain Softgels
Key product features
What you should know
Olly Ultra Strength Brain Softgels provide multiple science-backed ingredients to support long term cognitive health. They may be especially helpful in filling nutritional gaps in older adults’ diets.
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- The formula includes bacopa and blueberry extracts, omega-3 fatty acids, and B vitamins, all of which may support memory, learning, and overall brain health.
- At $0.83 per serving, these supplements are very affordable, while being NSF certified for content purity and potency.
- These are ideal for seniors looking to fill nutritional gaps and support cognitive health with a minimal calorie, sugar-free supplement.
Why we like Olly Ultra Strength Brain as best for seniors
Olly Ultra Strength Brain contains a blend of nutrients that may help protect against age-related cognitive decline by filling nutritional gaps in older adults’ diets.
Each two-softgel serving provides bacopa extract (300 milligrams), blueberry extract (200 milligrams), omega-3 fatty acids from fish oil (100 milligrams), vitamin B6 (2 milligrams), and vitamin B12 (50 micrograms).
Bacopa extract may modestly improve memory in older adults experiencing forgetfulness. (24) Blueberry extract is rich in antioxidant polyphenols. Multiple studies indicate that berry-based supplements and foods can improve learning, memory, and executive function in older adults. (25) Omega-3 fatty acids are essential for long-term brain health, and B vitamins play vital roles in supporting healthy brain communication. (2, 26)
Meeting nutritional needs with foods can be more challenging for older adults due to medically restricted diets, and changes in taste, smell, and dental health. Olly Ultra Strength Brain is a solid choice to fill nutritional gaps and provide assurance that essential nutrients for brain health are being met.
The capsules are rated as easy-to-swallow with a slight peppermint flavor, which can help the possible fish flavor. They are sugar-free and contain only ten calories per serving, making them suitable for most dietary plans.
This product is also NSF contents certified, meaning there’s been external verification of the product’s contents for reassurance that the label accurately reflects what’s in the product, and that it’s free from contaminants.
In addition to all of this, we appreciate this product offers a well-rounded formula to support brain health while remaining very affordable, costing just $0.83 per serving.
What customers are saying
Olly rates high among Amazon customers, receiving an average rating of 4.3 out of 5 from over 1,000 reviewers. Customers are happy with the improvements in focus, concentration, and energy they’re experiencing when using this product.
“I am a total skeptic when it comes to supplements. But OLLY Brain had such good reviews, I researched the ingredients. I have taken this product for two months now. My focus, concentration and especially my memory have improved well beyond what I could have thought possible. I highly recommend it.”
Gail R., verified Amazon customer
Lois G. agrees, saying the product “couldn’t be better” because “it works and I can see it.”
Despite the mostly positive reviews, some customers have reported dissatisfaction with the aftertaste from the softgels as well as side effects like stomach upset.
One Amazon customer shared that taking two capsules daily “bothered my stomach.” Leading them to take one a day only and sometimes skip a day.
Specs
| Active ingredients | Vitamin B6 (2 milligrams), vitamin B12 (50 micrograms), blueberry extract (200 milligrams), bacopa extract (300 milligrams), Omega-3 from fish oil (100 milligrams) |
| Form | Softgel |
| Cost per serving | $0.83 |
| Additional ingredients | Rice bran oil, gelatin, sorbitol, glycerin, water, beeswax, maltodextrin, sunflower lecithin, natural flavors, red iron oxide, titanium dioxide, carmine. |
| Certifications | Third-party tested, NSF certified |
| Special diets | Gluten-free |
| Returns/guarantee | 30-day returns |
Best supplement for brain function: Lifeforce Magnesium
Key product features
What you should know
Lifeforce is a high-dose magnesium supplement combining four types of magnesium to help replenish your body’s levels. Many people, especially older adults, lack sufficient magnesium in their diet, which can lead to cognitive dysfunction. Lifeforce aims to address this with a blend of highly absorbable magnesium forms, including one that may be particularly beneficial for brain function.
- Magnesium L-threonate, included in Lifeforce, may be uniquely helpful for brain function, according to a 2022 study, improving memory and cognition in adults. (30)
- A one-time order costs $2.17 per serving, but a monthly subscription reduces the price to about $1.50 per serving. The company also offers military discounts and the ability to purchase via health savings accounts.
- This supplement is ideal for those with symptoms of low magnesium, such as fatigue or low appetite, and who don’t get enough magnesium-rich foods in their diet.
Why we like Lifeforce Magnesium as best for brain function
Lifeforce combines four types of magnesium to help replenish your body’s magnesium levels. Magnesium is important for over 300 body functions, including brain function. Many people, especially older adults, don’t get enough magnesium from their diet, which can lead to cognitive dysfunction. (27, 28, 29) Lifeforce provides ample amounts of four different forms of magnesium that are easily absorbed by your body.
One type, magnesium L-threonate, may be especially good for brain function. Animal studies show that magnesium L-threonate is the best type for raising magnesium levels in the brain. A 2022 study found that taking two grams of magnesium L-threonate improved memory and cognition in adults aged 18 to 65. (30)
Taking magnesium supplements might also help you sleep better and feel less anxious, which can improve overall brain health and function. (31) Lifeforce includes magnesium glycinate, magnesium malate, and magnesium taurate, all known for their superior absorption, which may increase the chances of seeing benefits. (32)
Keep in mind, these studies are small with limitations, and more research is needed to prove how well magnesium supplements work. But, if you have symptoms of low magnesium, like feeling tired or having a low appetite, and you don’t eat enough foods with magnesium (like spinach, beans, nuts, and grains), a quality magnesium supplement may help. (27)
You’ll need to be willing to take four capsules, the recommended dose for this product. Unlike gelcaps, these are hypromellose capsules that are somewhat harder to swallow. On the plus side, they include magnolia bark, which some researchers believe can help with the mental strain of anxiety. (33)
If you place a one-time order, the cost is high—$2.17 per serving. Signing up for a monthly subscription will bring that down to about $1.50 per serving, comparable to other products on our list. Military discounts are also offered, and this product may be eligible to be purchased with a health savings account.
Specs
| Active ingredients | Magtein ® (magnesium l-threonate), magnesium bisglycinate chelate, ATA Mg ® (magnesium N-acetyltaurinate), dimagnesium malate, magnolia extract |
| Form | Hypromellose capsule |
| Cost per serving | $2.17 |
| Additional ingredients | Hypromellose (capsule shell), microcrystalline cellulose, magnesium stearate, silica |
| Certifications | None disclosed |
| Special diets | None |
| Returns/guarantee | 14-day returns |
Best brain supplement for menopause brain fog: Ancient Nutrition Regenerative Organic Certified Focused Brain
Key product features
What you should know
Ancient Nutrition Regenerative Organic Certified Focused Brain provides a convenient combination of vitamins, herbals, and probiotics that may help alleviate brain fog, a common symptom during menopause. (24, 34, 35, 36, 37, 38, 39)
- The product requires taking three capsules daily. This is a lot, but we feel good that these ingredients meet stringent, organic certification requirements.
- Priced at $1.33 per serving, this supplement is mid-range when it comes to competitive price point, and it comes with a 30-day money-back guarantee.
- This is a good fit for women experiencing menopause-related brain fog who are seeking a natural supplement to support cognitive function.
- Despite promising ingredients, the product lacks third-party testing, and the exact contents of the superfood blend are proprietary and unverified.
Why we like Ancient Nutrition Regenerative Organic Certified Focused Brain as best for menopause brain fog
Ancient Nutrition takes a three-pronged approach to supporting brain health by combining vitamins, herbals, and probiotics. This combination may help combat brain fog symptoms commonly experienced during menopause.
According to the National Council on Aging (NCOA), brain fog is a common complaint among women experiencing menopause, and may be linked to hormonal fluctuations. Multiple areas of the brain contain estrogen receptors. Fluctuations in estrogen hormone levels may be responsible for that fuzzy headed feeling. But nutrition plays a role too, and boosting your intake of brain-beneficial nutrients could help manage these symptoms. (34)
Ancient Nutrition contains several ingredients that may benefit the menopausal brain, including vitamin B12, an herbal superfood blend, and a probiotic.
Vitamin B12 helps make brain chemicals, which regulate mood and other brain activities. Aging affects your body’s ability to absorb B12 and deficiencies could cause symptoms like fatigue and poor brain function. (35)
The superfood blend, which includes lion’s mane, bacopa, and ginkgo, offers additional support. Lion’s mane contains phytoestrogens that might help alleviate depressive symptoms associated with low estrogen, as observed in some animal studies. (36) Bacopa has potential to improve memory in older adults experiencing forgetfulness, while ginkgo is often used to enhance memory and focus by improving blood flow to the brain, though studies on its effectiveness show mixed results. (24, 37)
Finally, the probiotic Bacillus subtilis AB22 addresses the connection between gut and brain health. Probiotics are live bacteria that colonize the gut, performing essential health-promoting functions. Lab and animal studies suggest that Bacillus subtilis may have brain-protective effects. (38, 39, 40)
While the ingredients are promising, more research is needed to fully understand their benefits and effects. Plus, the proprietary nature of the superfood blend makes it impossible to verify the exact contents and match dosages with those used in studies. Additionally, as with most multi-ingredient blends, there’s no research confirming all these ingredients work effectively and safely when used together.
Nonetheless, many people are looking for more natural alternatives for treating menopausal symptoms, and this can be a good option to discuss with your doctor.
You’ll need to take three capsules daily to achieve the full recommended dosage. This sounds like a lot to add to your diet, but we like that this product goes the extra mile to meet stringent organic certification requirements—highlighting their commitment to both quality and sustainability. Unfortunately, there’s no indication this product is tested by a third party lab for product contents and contaminants, though the company claims they complete testing for heavy metals.
One last thing we liked is that this product falls squarely in the middle of the road when it comes to market pricing, costing just $1.33 per serving with a 30-day money back guarantee.
What customers are saying
Only 18 customers have reviewed this product on Amazon, but they provided a very high 4.9 out of 5 average rating.
“It works.” I was so embarrassed because I couldn’t recall words. This made a huge difference for me.”
Leann, verified Amazon customer
Reviewer SPArmand praises the product, writing “I’ve tried other supplements before finding this one and it is by far the best I’ve found. Almost immediately I notice better focus, and significantly better short term memory. If I miss a dose I can tell. I’m a big fan!”
Other reviewers like that this product combines multiple clinically tested ingredients, but are still waiting for results.
Specs
| Active ingredients | Vitamin B12 (as Methylcobalamin), Superfood Blend Regenerative Organic Certified® Lion’s Mane Mushroom Mycelium, Regenerative Organic Certified® Lion’s Mane Myceliated Bacopa Brahmi Leaf Extract, Regenerative Organic Certified® Lion’s Mane Myceliated Ginkgo Leaf Extract, Bacillus subtilis AB22 |
| Form | Capsule |
| Cost per serving | $1.33 |
| Additional ingredients | Organic pullulan, organic apple cider vinegar |
| Certifications | USDA Organic, Regenerative Organic Certified (ROC) ® |
| Special diets | None |
| Returns/guarantee | 30-day returns |
How we test supplements
With our supplement product reviews, we aim to make taking care of your brain health easier. Our health experts thoroughly research each product’s ingredients for effectiveness and safety. We also evaluate customer experience, brand reputation, and overall product quality. This gives you the information you need to decide if a product is right for you. Read more about our full supplements testing methodology for more information on each factor.
Testing criteria
Efficacy—40%
We know real results are what you’re looking for, and that there’s no one-size-fits-all solution for brain health. This is why we rigorously examine each product’s formulation, ensuring evidence supports the claims they’re making.
Here’s what we look for:
- Clinical evidence
- Calories per serving
- Dose efficacy
- Synergistic effects
- Proprietary blends
Safety and side effects—35%
Risks and side effects are important to consider before taking any supplement. We make sure you know what these are, so you can weigh the pros and cons about what is right for your health goals.
We evaluate:
- Reported side effects
- Third-party testing
- Manufacturer accreditation
- Artificial sweeteners
Value—20%
To help ensure you’re getting the best value we consider factors like cost as well as effectiveness and convenience so you feel confident you’re spending your money wisely.
Our factors in this rating include:
- Price per serving
- Product format
- Storage and dosage requirements
- Usability
Customer experience—5%
We want to bring you solutions from companies that stand behind products by providing a positive customer experience. This helps support loyalty and consistency.
Our factors in this rating include:
- Ease of purchase
- Shipping and returns
- Customer support
Benefits of brain supplements
Brain health supplements, such as omega-3s, vitamin B12, and herbal extracts like ginkgo biloba and bacopa, may offer benefits like reduced brain fog and improved memory and focus. However, research on how individual nutrients and herbs affect brain performance is still limited. For instance, while omega-3 supplements are widely studied, the exact dosage required for brain health benefits remains uncertain. Moreover, it’s unclear whether these benefits stem from single nutrients or a combination of factors found in whole foods.
Additionally, many brain-boosting supplements, often called nootropics, have not been thoroughly tested for safety, so they should be used with caution.
Despite these limitations, supplements can still be valuable. They can help fill nutritional gaps, ensuring you get essential nutrients that might be hard to obtain from food alone. By combining a healthy diet with the right supplements, you can more effectively support your brain health than by relying on supplements alone.
What to consider when buying brain supplements
There’s no one-size-fits all best brain supplement. Here’s how to evaluate which options are best for you.
Assess your individual diet needs
Optimize your diet first, then choose a supplement to fill any nutrient gaps. While it’s tempting to pick supplements with multiple ingredients, more isn’t always better. You might end up paying for unnecessary components, and worst-case, they could possibly interact negatively. Instead, identify the brain-healthy foods you find hard to include and select a supplement that provides those specific nutrients.
Evaluate brand reputation and transparency
Dietary supplements are loosely regulated, meaning you have to rely on each brand to provide you with accurate product information. Here’s what to look for to determine if a brand is trustworthy:
- Label transparency: Trustworthy brands will tell you the exact ingredients and amounts used in their formulations. Be wary of proprietary blends that don’t disclose this information.
- Third-party testing: Certification by a third-party lab like USP, NSF or Informed Consent ensures that somebody outside of the company has verified that the product contains what it says it does and isn’t contaminated with harmful substances.
- Reasonable claims: While brain supplements may help support brain health and performance, there’s a lot we still don’t know about their effects. Avoid brands that make claims that sound too good to be true.
Consider cost and format
You’ll see the greatest benefits from supplements you consistently take. Make sure you choose options that you can afford long-term. You’ll also want to consider how well the supplement format fits with your lifestyle. For example, if you hate taking pills, opting for a powder or gummy format may help you stick to your supplement routine.
What to avoid in brain supplements
Here’s what to avoid in any brain health supplement:
- Added sugars: Eating too much sugar can negatively impact cognitive performance. (41)
- Too many ingredients: Many manufacturers overstuff their products with ingredients to stand out, but there’s little research on the effectiveness and interactions of multi-ingredient supplements. Simpler formulations help you identify which ingredients truly work.
- Claims that they cure or treat diseases: Avoid products that claim to treat or cure diseases—they can’t. Some can worsen health conditions or interact with medications, so consult your doctor before taking any.
Other ways to reduce brain fog
Beyond brain health supplements, several other strategies can help enhance mental clarity and overall brainpower.
Adopt a brain-healthy diet
The MIND diet, a combination of the Mediterranean and DASH diets, has been shown to help boost memory, focus, and overall cognitive health. (42) This diet recommends:
- Veggies: At least one serving daily, with six servings per week from green leafy vegetables like spinach and kale
- Whole grains: Three servings daily, such as quinoa, oats, and 100% whole grain pasta and breads
- Berries: Two servings per week of berries like blueberries and raspberries
- Nuts: Five servings weekly of any kind
- Olive oil: Use it as your primary cooking oil
- Fatty fish: Two servings weekly, such as sardines, tuna, salmon, and mackerel
- Beans: Four servings per week
- Poultry: Two servings weekly
- Wine: One glass daily or less
Stay hydrated
Drinking plenty of water is essential for maintaining optimal brain function. Dehydration can lead to cognitive decline, so aim to drink at least eight glasses of water a day. (43)
Limit intake of inflammatory foods
Foods high in sugar, refined carbs, and unhealthy fats can cause inflammation, which negatively affects brain health. Focus on eating a balanced diet rich in fruits, vegetables, lean proteins, and healthy fats. (44)
Stay active
Regular physical activity increases blood flow to the brain, which can improve cognitive function and reduce symptoms of brain fog. Aim for at least 30 minutes of moderate exercise most days of the week. (45)
Grab a cup of coffee
Caffeine can help improve energy and memory by stimulating the central nervous system. Enjoying a cup of coffee in the morning or during a midday slump can provide a temporary cognitive boost. Just be mindful of your caffeine intake to avoid dependence or negative side effects. (46)
Get adequate sleep
Sleep is vital for cognitive health. Aim for seven to nine hours of quality sleep each night to ensure your brain has time to rest and repair. Poor sleep can lead to increased brain fog and decreased cognitive performance. (47)
FAQs
Do any brain supplements really work?
Maybe, but current evidence is inconclusive. Foods rich in specific nutrients, like omega-3 fatty acids, magnesium, and B vitamins are linked to optimal brain health. (42) However, there’s not enough evidence to determine whether taking these nutrients through supplements provides the same benefits.
What is the best natural brain booster?
Caffeine is widely used as a natural brain booster. Studies show intake of up to 300 milligrams (about 24 ounces of coffee) can improve memory and brain performance. (46) But more isn’t better. Consistently consuming large amounts of caffeine can cause side effects like jitteriness and sleeplessness which can have a negative impact on brain function.
Are brain supplements worth it?
You’ll most likely benefit from brain supplements when you use them as part of a balanced diet, like the MIND or Mediterranean diets. Aim to personalize your supplement plan by choosing brain health supplements that fill nutrient gaps in your regular meals.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases.
Our experts
Victoria Burgess, Ph.D., CSCS, CISSN
Victoria Burgess earned her Ph.D. in Health and Human Performance from Concordia University Chicago and holds her NSCA CSCS and Certified Sports Nutritionist (CISSN). She is an adjunct professor in the Human Performance and Nutrition department at Concordia University Chicago & Parker University, where she teaches undergraduate, graduate, and doctoral-level courses.
Joana Neziri, M.S., NASM CPT
Joana is a writer, editor, and content strategist focusing on nutrition, fitness, and all things health. After earning a master’s degree in business from the University of North Florida, she began a career in research and digital marketing.
Lily Moe
Lily is a Brooklyn-based writer and editor with over seven years of experience in health media. As a former Fitness Coach, Lily’s editorial prowess has largely focused on fitness, nutrition, and weight management. She has also spent a fair share of time in testing labs, analyzing everything from protein powders to yoga mats. Her work has appeared in Verywell Fit, Verywell Mind, Health, and more.
Kelly Uhler
Kelly has a multifaceted background in elder care, health care, and copywriting. She has worked for organizations such as A Place For Mom and Homecare.com, which gave her the opportunity to work closely with families, providing reliable information to help them make informed decisions about their loved one’s health, safety, and quality of life.
Meghan Novoshielski, MS RDN
Fortune Recommends Nutrition Writer
About Author
Meghan is a Registered Dietitian Nutritionist (RDN) with over 15 years of experience in the nutrition field. She holds a Master’s in Nutrition Science and Policy from Tufts University and has helped create evidence-based, highly effective products for brands like Nutrisystem and Wawa to improve people’s health. As an experienced health writer, Meghan is passionate about motivating people to pursue their healthiest lives through trustworthy, practical, and engaging nutrition content. These days her health and fitness goals are all about staying strong and active to keep up with her three young and very energetic children.